Altered Na+-K+ ATPase immunoreactivity within GABAergic neurons in the gerbil hippocampal complex induced by spontaneous seizure and vigabatrin treatment

被引：18

作者：

Kang, TC ^{[1
]}

Park, SK ^{[1
]}

Hwang, IK ^{[1
]}

An, SJ ^{[1
]}

Won, MH ^{[1
]}

机构：

[1] Hallym Univ, Coll Med, Dept Anat, Chunchon 200702, South Korea

来源：

NEUROCHEMISTRY INTERNATIONAL | 2004年 / 45卷 / 01期

关键词：

Na+-K+ ATPase; epilepsy; hippocampus; gerbil; vigabatrin;

D O I：

10.1016/j.neuint.2003.10.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present study, the expression of Na+-K+ ATPase in the gerbil hippocampus associated with various sequelae of spontaneous seizures were investigated in order to identify the roles of Na+-K+ ATPase in the epileptogenesis and the recovery mechanisms in these animals. The population of Na+-K+ ATPase immunoreactive neurons and Na+-K+ ATPase immunodensity were significantly lower in the pre-seizure group of SS gerbils than those in SR gerbils. At 30-min postictal, the Na+-K+ ATPase immunoreactivity was significantly elevated in the hippocampal complex. At 3-h postictal, the Na+-K+ ATPase immunoreactivity in the hippocampus was declined, as compared to the 30-min postictal. At 12 h after seizure on-set, Na+-K+ ATPase expression was re-enhanced in the all regions of the hippocampal complex including the dentate hilus. Following administration of vigabatrin Na+-K+ ATPase expression was also increased. The present data suggest that altered Na+-K+ ATPase expression may contribute the regulation of the seizure activity in this animal. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：179 / 187

页数：9

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