Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes

被引:64
作者
Honnorat, J
Byk, T
Kusters, I
Aguera, M
Ricard, D
Rogemond, V
Quach, T
Aunis, D
Sobel, A
Mattei, MG
Kolattukudy, P
Belin, MF
Antoine, JC
机构
[1] Hop Neurol, INSERM, U433, F-69003 Lyon, France
[2] INSERM, U440, F-75005 Paris, France
[3] Ctr Neurochim, INSERM, U338, F-67084 Strasbourg, France
[4] Fac Med Marseille, INSERM, U406, F-13385 Marseille, France
[5] Ohio State Univ, Neurobiotechnol Ctr, Columbus, OH 43210 USA
[6] Hop Bellevue, Serv Neurol, F-42000 St Etienne, France
关键词
anti-CV2; autoantibodies; CRMP; oligodendrocytes; Unc33;
D O I
10.1046/j.1460-9568.1999.00864.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Anti-CV2 autoantibodies have recently been discovered in patients with paraneoplastic neurological diseases (PND). These disorders are associated with neuronal degeneration, mediated by autoimmune processes, in patients with systemic cancer. Anti-CV2 autoantibodies recognize a brain protein of 66 kDa developmentally regulated and specifically expressed by a subpopulation of oligodendrocytes in the adult brain. Here, we demonstrate that anti-CV2 sera recognize several post-translationally modified forms of Ulip4/CRMP3, a member of a protein family related to the axonal guidance and homologous to the Unc-33 gene product in Caenorhabditis elegans. The sequence of the human Ulip4/CRMP3 was determined and the gene localized to chromosome 10q25.2-q26, a region mutated in glioblastomas and containing tumour suppressor genes. The identification of the Ulip/CRMP proteins as recognized by anti-CV2 sera should provide new insights into the role of Ulip/CRMPs in oligodendrocytes and into pathophysiology of PND.
引用
收藏
页码:4226 / 4232
页数:7
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