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One-pot synthesis of 5-(substituted-amino)pyrazoles

被引：29
作者：
Dodd, DS
Martinez, RL
机构：
[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Early Discovery Chem, Princeton, NJ 08543 USA
[2] Bristol Myers Squibb Co, Pharmaceut Res Inst, New Leads Chem Appl Biotechnol, Princeton, NJ 08543 USA
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 22期
关键词：
5-Aminopyrazoles; 5-Alkylaminopyrazoles; beta-ketoamides;
D O I：
10.1016/j.tetlet.2004.04.017
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and mild one-pot synthesis of substituted 5-alkylamino and/or 5-(arylamino)pyrazoles is described. A suitably decorated beta-ketoamide, an aryl or alkyl hydrazine and Lawesson's reagent are suspended in THF/Py and gently heated to yield the requisite 5-aminopyrazoles. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4265 / 4267
页数：3
相关论文
共 13 条
[1]  
ABDELRAHMAN RM, 1994, PHARMAZIE, V49, P729
[2]   Studies towards the synthesis of Fipronil® analogues:: improved decarboxylation of α-hydrazonoacid derivatives [J].
Ancel, JE ;
El Kaïm, L ;
Gadras, A ;
Grimaud, L ;
Jana, NK .
TETRAHEDRON LETTERS, 2002, 43 (46) :8319-8321
[3]  
Atlan V, 2002, SYNLETT, P352
[4]  
Atlan V, 2000, SYNLETT, P489
[5]  
COOPER CB, 2002, Patent No. 02183461
[6]   An efficient and rapid synthesis of β-carboxamide derivatives using 2,2-dimethyl-2H,4H-1,3-dioxin-4-ones by microwave irradiation [J].
Miriyala, B ;
Williamson, JS .
TETRAHEDRON LETTERS, 2003, 44 (43) :7957-7959
[7]  
Moreno-Mañas M, 1999, SYNTHESIS-STUTTGART, P157
[8]   An efficient and general strategy for the synthesis of 4-phosphorylated pyrazoles from beta-hydrazono phosphine oxides. [J].
Palacios, F ;
Aparicio, D ;
delosSantos, JM .
TETRAHEDRON, 1996, 52 (11) :4123-4132
[9]   Preparation and improved stability of N-Boc-α-amino-5-acyl Meldrum's acids, a versatile class of building blocks for combinatorial chemistry [J].
Raillard, SP ;
Chen, WW ;
Sullivan, E ;
Bajjalieh, W ;
Bhandari, A ;
Baer, TA .
JOURNAL OF COMBINATORIAL CHEMISTRY, 2002, 4 (05) :470-474
[10]   Efficient synthesis of 5-alkyl amino and thioether substituted pyrazoles [J].
Sakya, SM ;
Rast, B .
TETRAHEDRON LETTERS, 2003, 44 (41) :7629-7632
12