Hepatitis C:: molecular virology and antiviral targets

被引：51

作者：

Moradpour, D ^{[1
]}

Brass, V ^{[1
]}

Gosert, R ^{[1
]}

Wölk, B ^{[1
]}

Blum, HE ^{[1
]}

机构：

[1] Univ Freiburg, Dept Med 2, D-79106 Freiburg, Germany

来源：

TRENDS IN MOLECULAR MEDICINE | 2002年 / 8卷 / 10期

关键词：

D O I：

10.1016/S1471-4914(02)02395-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic hepatitis C is a leading cause of liver cirrhosis and hepatocellular carcinoma worldwide. Although current treatment options are limited, progress in understanding the molecular virology of hepatitis C has led to the identification of novel antiviral targets. Moreover, in vitro and in vivo model systems have been developed that allow systematic evaluation of new therapeutic strategies. This review details current concepts in molecular virology and emerging therapies for hepatitis C.

引用

页码：476 / 482

页数：7

共 73 条

[1] Hepatitis C virus and other Flaviviridae viruses enter cells via low density lipoprotein receptor
Agnello, V
Abel, G
Elfahal, M
Knight, GB
Zhang, QX
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) : 12766 - 12771
[2] Characterization of low- and very-low-density hepatitis C virus RNA-containing particles
André, P
Komurian-Pradel, F
Deforges, S
Perret, M
Berland, JL
Sodoyer, M
Pol, S
Bréchot, C
Paranhos-Baccalà, G
Lotteau, V
[J]. JOURNAL OF VIROLOGY, 2002, 76 (14) : 6919 - 6928
[3] [Anonymous], 2000, VIRUS TAXONOMY 7 REP
[4] [Anonymous], FIELDS VIROLOGY
[5] Replication of hepatitis C virus
Bartenschlager, R
Lohmann, V
[J]. JOURNAL OF GENERAL VIROLOGY, 2000, 81 : 1631 - 1648
[6] Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection
Bassett, SE
Guerra, B
Brasky, K
Miskovsky, E
Houghton, M
Klimpel, GR
Lanford, RE
[J]. HEPATOLOGY, 2001, 33 (06) : 1479 - 1487
[7] Hepatitis C virus-like particle morphogenesis
Blanchard, E
Brand, D
Trassard, S
Goudeau, A
Roingeard, P
[J]. JOURNAL OF VIROLOGY, 2002, 76 (08) : 4073 - 4079
[8] Efficient initiation of HCV RNA replication in cell culture
Blight, KJ
Kolykhalov, AA
Rice, CM
[J]. SCIENCE, 2000, 290 (5498) : 1972 - 1974
[9] Molecular biology and gene therapy in gastroenterology and hepatology
Blum, HE
[J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 1999, 11 (01) : 1 - 7
[10] An amino-terminal amphipathic α-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A
Brass, V
Bieck, E
Montserret, R
Wölk, B
Hellings, JA
Blum, HE
Penin, F
Moradpour, D
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (10) : 8130 - 8139

← 1 2 3 4 5 6 7 8 →