Schwannian crystalline-like inclusions bodies (Fardeau-Engel bodies) revisited in peripheral neuropathies

被引:7
作者
Vital, C [1 ]
Bouillot, S [1 ]
Canron, MH [1 ]
Vital, A [1 ]
机构
[1] Univ Victor Segalen, Dept Neuropathol, F-33076 Bordeaux, France
关键词
axonopathy; crystalline inclusions; filaments; mitochondria; peripheral neuropathy; Schwann cell;
D O I
10.1080/01913120252934279
中图分类号
TH742 [显微镜];
学科分类号
摘要
In 1969, Fardeau and Engel described polygonal organelles containing crystalline-like structures located in the Schwann cell cytoplasm of unmyelinated fibers. Such inclusions were reported in various conditions, mainly with axonal lesions. They were also reported in a few cases of peripheral neuropathy associated with primary mitochondriopathy. Although they are surrounded by a double membrane, their mitochondrial origin is not definitely proven. Their significance remains obscure but they deserve to be better known as Fardeau-Engel bodies, so as not to be mistaken with mitochondrial crystalline inclusions, which are frequently observed in patients with ragged-red fibers in muscle.
引用
收藏
页码:9 / 13
页数:5
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