Inhibition of melanoma metastases by fenofibrate

被引：69

作者：

Grabacka, M

Placha, W

Plonka, PM

Pajak, S

Urbanska, K

Laidler, P

Slominski, A

机构：

[1] Temple Univ, Coll Sci & Technol, Ctr Neurovirol & Canc Biol, Philadelphia, PA 19122 USA

[2] Jagiellonian Univ, Collegium Medicum, Inst Biochem, PL-31034 Krakow, Poland

[3] Univ Tennessee, Ctr Hlth Sci, Dept Pathol & Lab Med, Memphis, TN 38163 USA

[4] Jagiellonian Univ, Fac Biotechnol, PL-30387 Krakow, Poland

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 2004年 / 296卷 / 02期

关键词：

chemoprevention; fenofibrate; metastases; PPAR; Syrian hamster; transplantable melanoma;

D O I：

10.1007/s00403-004-0479-y

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The effect of fenofibrate, a ligand of peroxisome proliferator-activated receptor (PPAR) alpha, on the growth and metastatic potential of Bomirski hamster melanoma s.c. tumors, pigmented line (BHM Ma) was investigated in vivo. RT-PCR and Western-blot analyses revealed the presence of mRNA and protein of PPAR alpha in BHM Ma cells. The animals treated orally with fenofibrate developed significantly fewer metastatic foci in the lungs, as compared to the control group; however, primary tumor growth remained unaltered. This observation is interesting in respect of the potential use of fenofibrate in melanoma chemoprevention.

引用

页码：54 / 58

页数：5

共 54 条

[1] EFFECTS OF FIBRIC ACID-DERIVATIVES ON ACCUMULATION OF ACTIN IN MYOCARDIOCYTES [J].