Addressing the problems with life-science databases for traditional uses and systems biology

被引:55
作者
Philippi, Stephan
Koehler, Jacob
机构
[1] Univ Koblenz, Dept Comp Sci, D-56016 Koblenz, Germany
[2] Rothamsted Res Harpenden, Biomath & Bioinformat Div, Harpenden AL5 2JQ, Herts, England
基金
奥地利科学基金会;
关键词
D O I
10.1038/nrg1872
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
A prerequisite to systems biology is the integration of heterogeneous experimental data, which are stored in numerous life-science databases. However, a wide range of obstacles that relate to access, handling and integration impede the efficient use of the contents of these databases. Addressing these issues will not only be essential for progress in systems biology, it will also be crucial for sustaining the more traditional uses of life-science databases.
引用
收藏
页码:482 / 488
页数:8
相关论文
共 64 条
[51]  
ROTHER K, 2004, P DAT INT LIF SCI 1, P156
[52]   Data integration - connecting the dots [J].
Searls, DB .
NATURE BIOTECHNOLOGY, 2003, 21 (08) :844-845
[53]  
Smith B, 2004, LECT N BIOINFORMAT, V2994, P79
[54]  
Spellman PT, 2002, GENOME BIOL, V3
[55]   The bioperl toolkit:: Perl modules for the life sciences [J].
Stajich, JE ;
Block, D ;
Boulez, K ;
Brenner, SE ;
Chervitz, SA ;
Dagdigian, C ;
Fuellen, G ;
Gilbert, JGR ;
Korf, I ;
Lapp, H ;
Lehväslaiho, H ;
Matsalla, C ;
Mungall, CJ ;
Osborne, BI ;
Pocock, MR ;
Schattner, P ;
Senger, M ;
Stein, LD ;
Stupka, E ;
Wilkinson, MD ;
Birney, E .
GENOME RESEARCH, 2002, 12 (10) :1611-1618
[56]   Integrating biological databases [J].
Stein, LD .
NATURE REVIEWS GENETICS, 2003, 4 (05) :337-345
[57]   TAMBIS: Transparent access to multiple bioinformatics information sources [J].
Stevens, R ;
Baker, P ;
Bechhofer, S ;
Ng, G ;
Jacoby, A ;
Paton, NW ;
Goble, CA ;
Brass, A .
BIOINFORMATICS, 2000, 16 (02) :184-185
[58]   Biological SOAP servers and web services provided by the public sequence data bank [J].
Sugawara, H ;
Miyazaki, S .
NUCLEIC ACIDS RESEARCH, 2003, 31 (13) :3836-3839
[59]   A systematic approach to modeling, capturing, and disseminating proteomics experimental data [J].
Taylor, CF ;
Paton, NW ;
Garwood, KL ;
Kirby, PD ;
Stead, DA ;
Yin, ZK ;
Deutsch, EW ;
Selway, L ;
Walker, J ;
Riba-Garcia, I ;
Mohammed, S ;
Deery, MJ ;
Howard, JA ;
Dunkley, T ;
Aebersold, R ;
Kell, DB ;
Lilley, KS ;
Roepstorff, P ;
Yates, JR ;
Brass, A ;
Brown, AJP ;
Cash, P ;
Gaskell, SJ ;
Hubbard, SJ ;
Oliver, SG .
NATURE BIOTECHNOLOGY, 2003, 21 (03) :247-254
[60]  
van Helden J, 2000, BIOL CHEM, V381, P921