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Nanosuspensions in drug delivery

被引：1171
作者：
Rabinow, BE [1 ]
机构：
[1] Baxter Healthcare Corp, Strateg Tech Dev, Round Lake, IL 60073 USA
来源：
NATURE REVIEWS DRUG DISCOVERY | 2004年 / 3卷 / 09期
关键词：
D O I：
10.1038/nrd1494
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A surprisingly large proportion of new drug candidates emerging from drug discovery programmes are water insoluble, and therefore poorly bioavailable, leading to abandoned development efforts. These so-called 'brickdust' candidates can now be rescued by formulating them into crystalline nanosuspensions. In the process of overcoming issues involving solubility, additional pharmacokinetic benefits of the drugs so formulated have come to be appreciated. As such, insolubility issues of the past have provoked a paradigm change, which now offers novel solutions for innovative drugs of the future.
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页码：785 / 796
页数：12
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