Possible gender-dependent association of vascular endothelial growth factor (VEGF) gene and ALS

被引：27

作者：

Fernandez-Santiago, R.

Sharma, M.

Mueller, J. C.

Gohlke, H.

Illig, T.

Anneser, J.

Munch, C.

Ludolph, A.

Kamm, C.

Gasser, T.

机构：

[1] Univ Tubingen, Dept Neurodegenerat Dis, Hertie Inst Brain Res, D-72076 Tubingen, Germany

[2] Univ Tubingen, Grad Sch Cellular & Mol Neurosci, Tubingen, Germany

[3] Univ Tubingen, Int Max Planck Res Sch, Tubingen, Germany

[4] Tech Univ Munich, Inst Med Stat & Epidemiol, Munich, Germany

[5] Tech Univ Munich, Inst Psychiat & Psychotherapy, Munich, Germany

[6] Tech Univ Munich, D-8000 Munich, Germany

[7] GSF, Natl Res Ctr Environm & Hlth, Inst Epidemiol, Neuherberg, Germany

[8] Univ Munich, Dept Neurol, D-8000 Munich, Germany

[9] Univ Munich, Grosshadern Univ Hosp, Munich, Germany

[10] Univ Hosp Ulm, Dept Neurol, Ulm, Germany

来源：

NEUROLOGY | 2006年 / 66卷 / 12期

关键词：

D O I：

10.1212/01.wnl.0000219756.71928.25

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Individuals homozygous for haplotypes -2578-A/-1154-A/-634-G or -2578-A/-1154-G/-634-G in the promoter/5'UTR of the VEGF gene have a 1.8-fold increased risk of ALS in several European populations. We did not observe any significant association with single markers, or haplotype pairs, in a German sample of 580 sporadic ALS patients and 628 controls. However, the promoter SNP-1154 (rs1570360) was associated with affection status in women (p = 0.036), suggesting that the VEGF effect may be dependent on the sex ratio of the sample.

引用

页码：1929 / 1931

页数：3

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