Histone methyltransferases and demethylases: regulators in balancing osteogenic and adipogenic differentiation of mesenchymal stem cells

被引:75
作者
Deng, Peng [1 ,2 ]
Chen, Qian-Ming [2 ]
Hong, Christine [3 ]
Wang, Cun-Yu [1 ,4 ]
机构
[1] Univ Calif Los Angeles, Sch Dent, Div Oral Biol & Med, Los Angeles, CA 90095 USA
[2] Sichuan Univ, West China Sch Stomatol, State Key Lab Oral Dis, Chengdu 610064, Peoples R China
[3] Univ Calif Los Angeles, Sch Dent, Sect Orthodont, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Henry Samueli Sch Engn & Appl Sci, Dept Bioengn, Los Angeles, CA 90095 USA
关键词
adipogenesis; histone methylation; histone lysine methyltransferase; histone lysine demethylase; mesenchymal stem cells; osteogenesis; TRANSCRIPTION FACTOR OSTERIX; DOMAIN-CONTAINING PROTEINS; EPIGENETIC REGULATION; MOUSE DEVELOPMENT; OSTEOBLAST DIFFERENTIATION; ADIPOCYTE DIFFERENTIATION; LYSINE DEMETHYLASES; SIGNALING PATHWAYS; GENE-EXPRESSION; APICAL PAPILLA;
D O I
10.1038/ijos.2015.41
中图分类号
R78 [口腔科学];
学科分类号
100302 [口腔临床医学];
摘要
Mesenchymal stem cells (MSCs) are characterized by their self-renewing capacity and differentiation potential into multiple tissues. Thus, management of the differentiation capacities of MSCs is important for MSC-based regenerative medicine, such as craniofacial bone regeneration, and in new treatments for metabolic bone diseases, such as osteoporosis. In recent years, histone modification has been a growing topic in the field of MSC lineage specification, in which the Su(var)3-9, enhancer-of-zeste, trithorax (SET) domain-containing family and the Jumonji C (JmjC) domain-containing family represent the major histone lysine methyltransferases (KMTs) and histone lysine demethylases (KDMs), respectively. In this review, we summarize the current understanding of the epigenetic mechanisms by which SET domain-containing KMTs and JmjC domain-containing KDMs balance the osteogenic and adipogenic differentiation of MSCs.
引用
收藏
页码:197 / 204
页数:8
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