The future of murine sepsis and trauma research models

被引：77

作者：

Efron, Philip A. ^{[1
]}

Mohr, Alicia M. ^{[1
]}

Moore, Frederick A. ^{[1
]}

Moldawer, Lyle L. ^{[1
]}

机构：

[1] Univ Florida, Coll Med, Dept Surg, Gainesville, FL 32610 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2015年 / 98卷 / 06期

基金：

美国国家卫生研究院;

关键词：

translation; immunity; MULTIPLE ORGAN DYSFUNCTION; INFLAMMATORY RESPONSE SYNDROME; PERSISTENT INFLAMMATION; CRITICAL ILLNESS; CECAL LIGATION; ANIMAL-MODELS; 2-HIT MODEL; MOUSE; INJURY; IMMUNOSUPPRESSION;

D O I：

10.1189/jlb.5MR0315-127R

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Recent comparisons of the murine and human transcriptome in health and disease have called into question the appropriateness of the use of murine models for human sepsis and trauma research. More specifically, researchers have debated the suitability of mouse models of severe inflammation that is intended for eventual translation to human patients. This mini-review outlines this recent research, as well as specifically defines the arguments for and against murine models of sepsis and trauma research based on these transcriptional studies. In addition, we review newer advancements in murine models of infection and injury and define what we envision as an evolving but viable future for murine studies of sepsis and trauma.

引用

页码：945 / 952

页数：8

共 64 条

[1]

Animal models in burn research [J].

Abdullahi, A. ;

Amini-Nik, S. ;

Jeschke, M. G. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2014, 71 (17) :3241-3255

[2]

EARLY EXPRESSION CHANGES OF COMPLEMENT REGULATORY PROTEINS AND C5A RECEPTOR (CD88) ON LEUKOCYTES AFTER MULTIPLE INJURY IN HUMANS [J].

Amara, Umme ;

Kalbitz, Miriam ;

Perl, Mario ;

Flierl, Michael A. ;

Rittirsch, Daniel ;

Weiss, Manfred ;

Schneider, Marion ;

Gebhard, Florian ;

Huber-Lang, Markus .

SHOCK, 2010, 33 (06) :568-575

[3]

Sepsis and Scientific Revolutions [J].

Artenstein, Andrew W. ;

Higgins, Thomas L. ;

Opal, Steven M. .

CRITICAL CARE MEDICINE, 2013, 41 (12) :2770-2772

[4]

Baue AE, 1997, ARCH SURG-CHICAGO, V132, P703

[5]

Sepsis, systemic inflammatory response syndrome, multiple organ dysfunction syndrome, and multiple organ failure: Are trauma surgeons lumpers or splitters? [J].

Baue, AE .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2003, 55 (05) :997-998

[6]

Bible L. E., 2015, J TRAUMA AC IN PRESS

[7]

Early Blood Product and Crystalloid Volume Resuscitation: Risk Association With Multiple Organ Dysfunction After Severe Blunt Traumatic Injury [J].

Brakenridge, Scott C. ;

Phelan, Herb A. ;

Henley, Steven S. ;

Golden, Richard M. ;

Kashner, T. Michael ;

Eastman, Alexander E. ;

Sperry, Jason L. ;

Harbrecht, Brian G. ;

Moore, Ernest E. ;

Cuschieri, Joseph ;

Maier, Ronald V. ;

Minei, Joseph P. .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2011, 71 (02) :299-305

[8]

Some experiences and opportunities for big data in translational research [J].

Chute, Christopher G. ;

Ullman-Cullere, Mollie ;

Wood, Grant M. ;

Lin, Simon M. ;

He, Min ;

Pathak, Jyotishman .

GENETICS IN MEDICINE, 2013, 15 (10) :802-809

[9]

NIH to balance sex in cell and animal studies [J].

Clayton, Janine A. ;

Collins, Francis S. .

NATURE, 2014, 509 (7500) :282-283

[10]

A New Initiative on Precision Medicine [J].

Collins, Francis S. ;

Varmus, Harold .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (09) :793-795

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