Activation of nucleophilic fluorination by salts in ionic liquids and in sulfolane

被引：18

作者：

Anguille, Stephane

Garayt, Maxime

Schanen, Vincent

Gree, Rene

机构：

[1] Ecole Natl Super Chim Rennes, Lab Synth & Activat Biomol, CNRS, UMR 6052, F-35700 Rennes, France

[2] Rhodia Rech & Technol, Ctr Rech St Fons, F-69192 St Fons, France

[3] Univ Rennes 1, Lab Synth & Electrosynth Organ, CNRS, UMR 6510, F-35042 Rennes, France

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2006年 / 348卷 / 10-11期

关键词：

fluorides; fluorination; halogen exchange; ionic liquids; nucleophilic substitution; salt effect;

D O I：

10.1002/adsc.200606086

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The nucleophilic substitution of PhCCl3 by KF in imidazolium-type RTILs is faster than in classical organic solvents but it is strongly dependent upon the nature of the counteranion. The addition of bromide salts in substoichoimetric amounts to the [bmim][PF6] solvent strongly accelerates this reaction. Furthermore, it has been discovered that addition of KPF6 to the reaction mixtures strongly activates the nucleophilic fluorination by KF, not only in the [bmim][NTf2] or [bmim][PF6] ionic liquids but also for the reactions performed in sulfolane.

引用

页码：1149 / 1153

页数：5

共 49 条

[1] Synthesis and preliminary use of novel acrylic ester-derived task-specific ionic liquids [J].