Future directions in genetic for autoimmune diseases

被引：47

作者：

Invernizzi, Pietro ^{[1
,2
]}

机构：

[1] IRCCS Ist Clin Humanitas, Div Internal Med, I-20089 Milan, Italy

[2] IRCCS Ist Clin Humanitas, Hepatobiliary Immunopathol Unit, I-20089 Milan, Italy

来源：

JOURNAL OF AUTOIMMUNITY | 2009年 / 33卷 / 01期

关键词：

Genetic factors; Female preponderance; Etiopathogenesis; X-CHROMOSOME INACTIVATION; SYSTEMIC-LUPUS-ERYTHEMATOSUS; THYROID AUTOIMMUNITY; COMPLEX; SEX; MONOSOMY; FEMALES; GENDER; RATIOS; WOMEN;

D O I：

10.1016/j.jaut.2009.03.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune diseases affect cumulatively 5-10% of the general population and are multifactorial in their pathogenesis, with both inherited and environmental components. Although our knowledge of their pathogenesis has become more refined, diagnosis more accurate, and therapy more effective, the reasons for their development and the female preponderance of these diseases are still unknown. One of the most intriguing hypothesis to explain the female preponderance is related to sex chromosomes as, women affected by autoimmune diseases have a higher rate of circulating cells with a single X chromosome. In addition, a number of evidences suggest a role of X chromosome gene dosage in autoimmunity. Based on these findings, sex chromosome defects might be the common trait of the susceptibility to autoimmune diseases. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1 / 2

页数：2

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