The role of the X chromosome in immunity and autoimmunity

被引：26

作者：

Hernandez-Molina, Gabriela

Svyryd, Yevgeniya

Sanchez-Guerrero, Jorge

Mutchinick, Osvaldo M.

机构：

[1] INCMNSZ, Dept Inmunol & Reumatol, Secc 15, Mexico City 14000, DF, Mexico

[2] INCMNSZ, Dept Genet, Mexico City 14000, DF, Mexico

来源：

AUTOIMMUNITY REVIEWS | 2007年 / 6卷 / 04期

基金：

美国国家卫生研究院; 欧洲研究理事会;

关键词：

X chromosome; immunity; autoimmune disorders;

D O I：

10.1016/j.autrev.2006.08.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Primary immunodeficiencies as well as autoimmune diseases have been associated to X chromosome abnormalities. Furthermore, the functional biology of the X chromosome is unique because genes located in this chromosome can undergo inactivation, and subsequently transcriptional silencing. Non-random X chromosome inactivation has been hypothesized to be involved in the development of autoimmunity. Recently X chromosome monosomy has also been proposed as a common etiologic mechanism for some autoimmune diseases. Herein, we review some of these findings above mentioned. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：218 / 222

页数：5

共 26 条

[1] High frequency of skewed X-chromosome inactivation in females with autoimmune thyroid disease:: A possible explanation for the female predisposition to thyroid autoimmunity [J].