The role of the X chromosome in immunity and autoimmunity

被引：26

作者：

Hernandez-Molina, Gabriela

Svyryd, Yevgeniya

Sanchez-Guerrero, Jorge

Mutchinick, Osvaldo M.

机构：

[1] INCMNSZ, Dept Inmunol & Reumatol, Secc 15, Mexico City 14000, DF, Mexico

[2] INCMNSZ, Dept Genet, Mexico City 14000, DF, Mexico

来源：

AUTOIMMUNITY REVIEWS | 2007年 / 6卷 / 04期

基金：

美国国家卫生研究院; 欧洲研究理事会;

关键词：

X chromosome; immunity; autoimmune disorders;

D O I：

10.1016/j.autrev.2006.08.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Primary immunodeficiencies as well as autoimmune diseases have been associated to X chromosome abnormalities. Furthermore, the functional biology of the X chromosome is unique because genes located in this chromosome can undergo inactivation, and subsequently transcriptional silencing. Non-random X chromosome inactivation has been hypothesized to be involved in the development of autoimmunity. Recently X chromosome monosomy has also been proposed as a common etiologic mechanism for some autoimmune diseases. Herein, we review some of these findings above mentioned. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：218 / 222

页数：5

共 26 条

[11] X-chromosome inactivation in monozygotic twins with systemic lupus erythematosus [J].

Huang, QR ;

Parfitt, A ;

Grennan, DM ;

Manolios, N .

AUTOIMMUNITY, 1997, 26 (02) :85-93

[12] X chromosome monosomy: A common mechanism for autoimmune diseases [J].

Invernizzi, P ;

Miozzo, M ;

Selmi, C ;

Persani, L ;

Battezzati, PM ;

Zuin, M ;

Lucchi, S ;

Meroni, PL ;

Marasini, B ;

Zeni, S ;

Watnik, M ;

Grati, FR ;

Simoni, G ;

Gershwin, ME ;

Podda, M .

JOURNAL OF IMMUNOLOGY, 2005, 175 (01) :575-578

[13] Frequency of monosomy X in women with primary biliary cirrhosis [J].

Invernizzi, P ;

Miozzo, M ;

Battezzati, PM ;

Bianchi, I ;

Grati, FR ;

Simoni, G ;

Selmi, C ;

Watnik, M ;

Gershwin, ME ;

Podda, M .

LANCET, 2004, 363 (9408) :533-535

[14] KLINEFELTERS-SYNDROME ASSOCIATED WITH PROGRESSIVE SYSTEMIC-SCLEROSIS - REPORT OF A CASE AND REVIEW OF THE LITERATURE [J].

KOBAYASHI, S ;

SHIMAMOTO, T ;

TANIGUCHI, O ;

HASHIMOTO, H ;

HIROSE, S .

CLINICAL RHEUMATOLOGY, 1991, 10 (01) :84-86

[15] Cytokines and immunodeficiency diseases [J].

Leonard, WJ .

NATURE REVIEWS IMMUNOLOGY, 2001, 1 (03) :200-208

[16] Genome and hormones: Gender differences in physiology - Invited review: Sex ratio and rheumatic disease [J].

Lockshin, MD .

JOURNAL OF APPLIED PHYSIOLOGY, 2001, 91 (05) :2366-2373

[17] Primary immunodeficiencies and the rheumatologist [J].

O'Shea, JJ ;

Holland, S ;

Candotti, F .

CURRENT OPINION IN RHEUMATOLOGY, 2003, 15 (04) :413-416

[18] Skewed X chromosome inactivation in blood cells of women with scleroderma [J].

Özbalkan, Z ;

Bagislar, S ;

Kiraz, S ;

Akyerli, CB ;

Özer, HTE ;

Yavuz, S ;

Birlik, AM ;

Çalgüneri, M ;

Özçelik, T .

ARTHRITIS AND RHEUMATISM, 2005, 52 (05) :1564-1570

[19] Inherited disorders of NF-κB-mediated immunity in man [J].

Puel, A ;

Picard, C ;

Ku, CL ;

Smahi, A ;

Casanova, JL .

CURRENT OPINION IN IMMUNOLOGY, 2004, 16 (01) :34-41

[20] The DNA sequence of the human X chromosome [J].

Ross, MT ;

Grafham, DV ;

Coffey, AJ ;

Scherer, S ;

McLay, K ;

Muzny, D ;

Platzer, M ;

Howell, GR ;

Burrows, C ;

Bird, CP ;

Frankish, A ;

Lovell, FL ;

Howe, KL ;

Ashurst, JL ;

Fulton, RS ;

Sudbrak, R ;

Wen, GP ;

Jones, MC ;

Hurles, ME ;

Andrews, TD ;

Scott, CE ;

Searle, S ;

Ramser, J ;

Whittaker, A ;

Deadman, R ;

Carter, NP ;

Hunt, SE ;

Chen, R ;

Cree, A ;

Gunaratne, P ;

Havlak, P ;

Hodgson, A ;

Metzker, ML ;

Richards, S ;

Scott, G ;

Steffen, D ;

Sodergren, E ;

Wheeler, DA ;

Worley, KC ;

Ainscough, R ;

Ambrose, KD ;

Ansari-Lari, MA ;

Aradhya, S ;

Ashwell, RIS ;

Babbage, AK ;

Bagguley, CL ;

Ballabio, A ;

Banerjee, R ;

Barker, GE ;

Barlow, KF .

NATURE, 2005, 434 (7031) :325-337

← 1 2 3 →