Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy

被引：219

作者：

Li, Jingming ^{[1
,2
]}

Wang, Joshua J. ^{[1
,2
]}

Yu, Qiang ^{[3
]}

Wang, Min ^{[1
,2
]}

Zhang, Sarah X. ^{[1
,2
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Harold Hamm Oklahoma Diabet Ctr, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Sect Endocrinol & Diabet, Oklahoma City, OK 73104 USA

[3] Sun Yat Sen Univ, State Key Lab Ophthalmol, Zhongshan Ophthalm Ctr, Guangzhou 510060, Guangdong, Peoples R China

来源：

FEBS LETTERS | 2009年 / 583卷 / 09期

关键词：

ER stress; Inflammation; Diabetic retinopathy; Oxygen-induced retinopathy; Human retinal endothelial cell; ENDOTHELIAL GROWTH-FACTOR; OXYGEN-INDUCED RETINOPATHY; UNFOLDED PROTEIN RESPONSE; EPITHELIUM-DERIVED FACTOR; TRANSCRIPTION FACTOR; OXIDATIVE STRESS; VASCULAR LEAKAGE; NAD(P)H OXIDASE; MACULAR EDEMA; MOUSE MODEL;

D O I：

10.1016/j.febslet.2009.04.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetic retinopathy is a chronic low-grade inflammatory disease; however, the mechanisms remain elusive. In the present study, we demonstrated that endoplasmic reticulum (ER) stress was activated in the retina in animal models of diabetes and oxygen-induced retinopathy (OIR). Induction of ER stress by tunicamycin resulted in significantly increased expression of inflammatory molecules in the retina. Inhibition of ER stress by chemical chaperone 4- phenyl butyric acid ameliorated inflammation in cultured human retinal endothelial cells exposed to hypoxia, and in the retinas of diabetic and OIR mice. These findings indicate that ER stress is a potential mediator of retinal inflammation in diabetic retinopathy. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

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页码：1521 / 1527

页数：7

相关论文

共 40 条

[1] The Ins2Akita mouse as a model of early retinal complications in diabetes [J].

Barber, AJ ;

Antonetti, DA ;

Kern, TS ;

Reiter, CEN ;

Soans, RS ;

Krady, JK ;

Levison, SW ;

Gardner, TW ;

Bronson, SK .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46 (06) :2210-2218

[2] The regulation of the induction of vascular endothelial growth factor at the onset of diabetes in spontaneously diabetic rats [J].

Braun, L ;

Kardon, T ;

Reisz-Porszasz, Z ;

Banhegyi, G ;

Mandl, J .

LIFE SCIENCES, 2001, 69 (21) :2533-2542

[3] Retinopathy of prematurity [J].

Chen J. ;

Smith L.E.H. .

Angiogenesis, 2007, 10 (2) :133-140

[4] Retinopathy is reduced during experimental diabetes in a mouse model of outer retinal degeneration [J].

de Gooyer, Tanyth E. ;

Stevenson, Kathryn A. ;

Humphries, Pete ;

Simpson, David A. C. ;

Gardiner, Tom A. ;

Stitt, Alan W. .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2006, 47 (12) :5561-5568

[5] Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium -: Implications in atherogenesis [J].

Dickhout, JG ;

Hossain, GS ;

Pozza, LM ;

Zhou, J ;

Lhoták, S ;

Austin, RC .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (12) :2623-2629

[6] Diabetic retinopathy [J].

Frank, RN .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (01) :48-58

[7] Association of Vitreous Inflammatory Factors with Diabetic Macular Edema [J].

Funatsu, Hideharu ;

Noma, Hidetaka ;

Mimura, Tatsuya ;

Eguchi, Shuichiro ;

Hori, Sadao .

OPHTHALMOLOGY, 2009, 116 (01) :73-79

[8] The unfolded protein response is an important regulator of inflammatory genes in endothelial cells [J].

Gargalovic, Peter S. ;

Gharavi, Nima M. ;

Clark, Michael J. ;

Pagnon, Joanne ;

Yang, Wen-Pin ;

He, Aiqing ;

Truong, Amy ;

Baruch-Oren, Tamar ;

Berliner, Judith A. ;

Kirchgessner, Todd G. ;

Lusis, Aldons J. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (11) :2490-2496

[9] Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids [J].

Gargalovic, Peter S. ;

Imura, Minori ;

Zhang, Bin ;

Gharavi, Nima M. ;

Clark, Michael J. ;

Pagnon, Joanne ;

Yang, Wen-Pin ;

He, Aiqing ;

Truong, Amy ;

Patel, Shilpa ;

Nelson, Stanley F. ;

Horvath, Steve ;

Berliner, Judith A. ;

Kirchgessner, Todd G. ;

Lusis, Aldons J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (34) :12741-12746

[10] Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression [J].

Hu, P ;

Han, Z ;

Couvillon, AD ;

Kaufman, RJ ;

Exton, JH .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (08) :3071-3084

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