High dietary phosphate intake reduces bone strength in the growing rat skeleton

被引：50

作者：

Huttunen, Minna M. ^{[1
]}

Tillman, Ilse

Viljakainen, Heli T.

Tuukkanen, Juha

Peng, ZhiQi

Pekkinen, Minna

Lamberg-Allardt, Christel J. E.

机构：

[1] Univ Helsinki, Dept Appl Chem & Microbiol, Calcium Res Unit, FIN-00014 Helsinki, Finland

[2] Univ Oulu, Dept Anat, FIN-90570 Oulu, Finland

[3] Univ Turku, Inst Biomed, Dept Anat, SF-20500 Turku, Finland

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 01期

关键词：

bone; bone strength; dietary phosphate; PTH; rat;

D O I：

10.1359/JBMR.061009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nutrition influences peak bone mass development in early adulthood. The effect of high dietary phosphate intake on the growing skeleton of I-month-old male rats (n = 30) was assessed in an 8-week intervention. High dietary phosphate intake increased bone remodeling and impaired bone material properties, diminishing bone mechanical strength.

引用

页码：83 / 92

页数：10