Effect of quinacrine, a phospholipase A(2) inhibitor on stress and chemically induced gastroduodenal ulcers

被引:15
作者
AlMoutaery, AR
Tariq, M
机构
[1] ARMED FORCES HOSP, RES CTR, RIYADH 11159, SAUDI ARABIA
[2] KING FAISAL UNIV, COLL MED, DEPT BIOCHEM, DAMMAM, SAUDI ARABIA
关键词
quinacrine; phospholipase A(2) inhibitor; gastric ulcers; duodenal ulcers; nonprotein sulfhydryls;
D O I
10.1159/000201435
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Quinacrine, a phospholipase Az inhibitor, has been studied for its ability to inhibit gastric secretion and to protect the gastric and duodenal mucosa against chemically and stress-induced ulcers. Acid secretion studies were undertaken in pylorus-ligated rats with and without quinacrine treatment. Experimental gastric lesions were induced by water-immersion restraint stress, indomethacin and 80% ethanol in rats; whereas duodenal ulcers were produced by treatment of rats with cysteamine. The level of nonprotein sulfhydryl compounds and gastric wall mucus were also measured in the glandular stomach of the rats following ethanol-induced gastric lesions. The results of this study demonstrate that quinacrine produces a dose-dependent inhibition of gastric acid secretion in rats. Pretreatment with quinacrine significantly attenuated the formation of stress-, indomethacin- and ethanol-induced gastric lesions. Quinacrine also protected intestinal mucosa against cysteamine induced duodenal ulcers. The antiulcer activity of quinacrine was associated with appreciable inhibition of ethanol-induced depletion of nonprotein sulfhydryls and gastric wall mucus. These findings point towards the mediation of sulfhydryls in quinacrine-induced gastrointestinal cytoprotection. In conclusion, this study demonstrates that quinacrine possesses significant antiulcer and cytoprotective activity against various experimentally induced gastroduodenal lesions. Although the mechanism of action of quinacrine requires further evaluation, the experimental observations derived from this study may have future clinical relevance and therefore deserve to be investigated thoroughly.
引用
收藏
页码:129 / 137
页数:9
相关论文
共 90 条
[1]   THE GASTRIC-MUCOSAL EPITHELIAL BARRIER - ROLE OF MUCUS AND FIBRIN [J].
ALLEN, A ;
SELLERS, LA ;
BENNETT, MK .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1987, 22 :6-13
[2]   THE ROLE OF MUCUS IN THE PROTECTION OF THE GASTRODUODENAL MUCOSA [J].
ALLEN, A ;
HUTTON, DA ;
LEONARD, AJ ;
PEARSON, JP ;
SELLERS, LA .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1986, 21 :71-78
[3]  
ARMSTRONG SC, 1991, AM J PATHOL, V138, P545
[4]   MEDIATORS OF LEUKOCYTE ADHESION IN RAT MESENTERIC VENULES ELICITED BY INHIBITION OF NITRIC-OXIDE SYNTHESIS [J].
ARNDT, H ;
RUSSELL, JB ;
KUROSE, I ;
KUBES, P ;
GRANGER, DN .
GASTROENTEROLOGY, 1993, 105 (03) :675-680
[5]   NAFAZATROM-INDUCED SALVAGE OF ISCHEMIC MYOCARDIUM IN ANESTHETIZED DOGS IS MEDIATED THROUGH INHIBITION OF NEUTROPHIL FUNCTION [J].
BEDNAR, M ;
SMITH, B ;
PINTO, A ;
MULLANE, KM .
CIRCULATION RESEARCH, 1985, 57 (01) :131-141
[6]   PROPERTIES OF GASTRIC AND DUODENAL MUCUS - EFFECT OF PROTEOLYSIS, DISULFIDE REDUCTION, BILE, ACID, ETHANOL, AND HYPERTONICITY ON MUCUS GEL STRUCTURE [J].
BELL, AE ;
SELLERS, LA ;
ALLEN, A ;
CUNLIFFE, WJ ;
MORRIS, ER ;
ROSSMURPHY, SB .
GASTROENTEROLOGY, 1985, 88 (01) :269-280
[7]   MECHANISM OF ULCEROGENIC ACTIVITY OF INDOMETHACIN AND OXYPHENBUTAZONE [J].
BHARGAVA, KP ;
GUPTA, MB ;
TANGRI, KK .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1973, 22 (02) :191-195
[8]  
BOROS M, 1993, SURGERY, V113, P184
[9]   EFFECT OF RESTRAINT ON GASTRIC ACIDITY IN RAT [J].
BRODIE, DA ;
MARSHALL, RW ;
MORENO, OM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1962, 202 (04) :812-&
[10]   REDUCTION IN INFARCT SIZE BY THE PHOSPHOLIPASE INHIBITOR QUINACRINE IN DOGS WITH CORONARY-ARTERY OCCLUSION [J].
CHIARIELLO, M ;
AMBROSIO, G ;
CAPPELLIBIGAZZI, M ;
PERRONEFILARDI, P ;
TRITTO, I ;
NEVOLA, E ;
GOLINO, P .
AMERICAN HEART JOURNAL, 1990, 120 (04) :801-807