Use of benzyloxycarbonyl (Z)-based fluorophilic tagging reagents in the purification of synthetic peptides

被引：64

作者：

Filippov, DV

van Zoelen, DJ

Oldfield, SP

van der Marel, GA

Overkleeft, HS

Drijfhout, JW

van Boom, JH

机构：

[1] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Immunohematol & Bloodtransfus, NL-2300 RC Leiden, Netherlands

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 43期

关键词：

D O I：

10.1016/S0040-4039(02)01723-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three novel fluorous reagents (i.e. 1-3), derived from benzyl chloroformate (Z-Cl), have been synthesized and used for the tagging of peptides prepared following a Fmoc-based solid-phase approach. It is shown that the implementation of a benzyloxycarbonyl (Z)-based fluorophilic tag facilitates purification of peptides using fluorous reverse phase chromatography. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：7809 / 7812

页数：4

共 17 条

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