The effect of preceding context on inhibition: An event-related fMRI study

被引:249
作者
Durston, S [1 ]
Thomas, KM
Worden, MS
Yang, Y
Casey, BJ
机构
[1] Cornell Univ, Weill Med Coll, Sackler Inst Dev Psychobiol, New York, NY 10021 USA
[2] Univ Utrecht, Med Ctr, Dept Child & Adolescent Psychiat, NL-3508 TC Utrecht, Netherlands
[3] Cornell Univ, Weill Med Coll, Dept Psychiat, New York, NY USA
关键词
functional MRI; event-related; inhibition; context;
D O I
10.1006/nimg.2002.1074
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In this study we combined event-related fMRI with a parametric manipulation of the go nogo paradigm to examine the effect of preceding context on inhibitory processes. Nogo trials were preceded by either 1, 3, or 5 go trials and then compared to one another. Two distinct patterns of activation were associated with behavioral inhibition: First, the ventral prefrontal cortex, cingulate gyrus, and superior parietal regions showed a context effect with an increase in MR signal to nogo trials with increasing number of preceding go trials. Second, anterior regions in the supplementary and premotor cortex showed an increase in AM signal on the nogo condition after 5 preceding go trials, but not after only 1 or 3. A model using the BOLD response in our data was used to verify that the effect of context was not an artifact of the randomization scheme used in the design. (C) 2002 Elsevier Science (USA).
引用
收藏
页码:449 / 453
页数:5
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