Stimulus/response curves as a method of measuring motor cortical excitability in man

被引：300

作者：

Ridding, MC ^{[1
]}

Rothwell, JC ^{[1
]}

机构：

[1] INST NEUROL,MRC,HUMAN MOVEMENT & BALANCE UNIT,LONDON WC1N 3BG,ENGLAND

来源：

ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY | 1997年 / 105卷 / 05期

关键词：

magnetic stimulation; human motor cortex; mapping;

D O I：

10.1016/S0924-980X(97)00041-6

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We investigated whether input/output curves of human motor cortex could provide similar information to cortical mapping under two conditions where the motor maps are known to change dramatically: ischaemic anaesthesia and amputation. Stimulus/response curves were constructed by recording the size of EMG responses evoked in arm muscles with transcranial magnetic stimulation at a single site using a range of intensities. Changes in the slope of this relationship during ischaemic anaesthesia (6 normal subjects) or amputation (two patients) were compared to changes in cortical motor maps produced by stimulating different sites at the same intensity. At rest both interventions increased map areas, as well as the slope of the stimulus/response curves. During voluntary activity they had no effect. We conclude that stimulus/response curves can detect changes in cortical motor maps, and discuss potential mechanisms for this effect. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：340 / 344

页数：5

共 18 条

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