Vitamin B12 levels during prolonged treatment with proton pump inhibitors

被引：77

作者：

Howden, CW ^{[1
]}

机构：

[1] Northwestern Univ, Clin Res Ctr, Chicago, IL 60611 USA

来源：

JOURNAL OF CLINICAL GASTROENTEROLOGY | 2000年 / 30卷 / 01期

关键词：

cobalamin; omeprazole; lansoprazole; absorption;

D O I：

10.1097/00004836-200001000-00006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Reduced serum vitamin B-12 (cobalamin) levels have been documented occasionally during long-term treatment with a proton pump inhibitor (PPI) in selected groups of patients. This has largely been confined to patients being treated for Zollinger-Ellison syndrome who have sustained drug-induced achlorhydria, which does not ordinarily occur during treatment with a PPI. An appreciation of normal cobalamin metabolism and the pharmacological action of the PPIs adequately explain the mechanism for this reduction. PPIs do not promote the development of pernicious anemia.

引用

页码：29 / 33

页数：5

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