A modified palladium catalysed reductive amination procedure

被引：40

作者：

Berdini, V

Cesta, MC

Curti, R

D'Anniballe, G

Di Bello, N

Nano, G

Nicolini, L

Topai, A

Allegretti, M

机构：

[1] Astex Technol, Cambridge CB4 0WE, England

[2] Dompe SpA, Ctr Res & Dev, Dept Chem, I-67100 Laquila, Italy

来源：

TETRAHEDRON | 2002年 / 58卷 / 28期

关键词：

reductive amination; palladium catalysis; tropanone; 3-endotropanamine; hemiaminal; ammonium formate;

D O I：

10.1016/S0040-4020(02)00530-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New, extended applications of a modified palladium catalysed reductive amination procedure are described; a mechanistic hypothesis alternative to the common imine pathway is proposed. This versatile method advances the usual reductive amination processes in terms of yield and shows high stereoselectivity whether applied to constrained carbonyl compounds. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：5669 / 5674

页数：6

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