Rubescensins S and T:: Seco-ent-kaurane diterpenoids from Isodon rubescens var. taihangensis

被引：33

作者：

Han, QB

Li, RT

Zhang, JX

Sun, HD ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources, Kunming 650204, Peoples R China

[2] Xinxiang Med Coll, Dept Chem, Henan 453000, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2004年 / 87卷 / 05期

关键词：

D O I：

10.1002/hlca.200490102

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new diterpenoids, rubescensin S (=(1alpha,6beta,14beta)-7alpha,20-epoxy-1,7,14-trihydroxy-16-oxo-15,16-seco-entkauran-6,15-olide; 1) and rubescensin T (=(1alpha,6beta,11beta,20S)-7alpha,20-epoxy-1,6,7-trihydroxy-20-methoxy-8,15-seco-ent-kaur-16-en-11,15-olide; 2) were isolated from the Chinese medicinal herb Isodon rubescens var. taihangensis. Compound 1 possesses a unique, unprecedented 15,16-seco-ent-kaurane skeleton. Both compounds exhibited cytotoxic activities against K562 human leukemia cells.

引用

页码：1119 / 1124

页数：6

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