Anti-HIV agents derived from the ent-kaurane diterpenoid linearol

被引：32

作者：

Bruno, M

Rosselli, S

Pibiri, I

Kilgore, N

Lee, KH

机构：

[1] Univ Palermo, Dipartimento Chim Organ, I-90128 Palermo, Italy

[2] Panacos Pharmaceut Inc, Gaithersburg, MD 20879 USA

[3] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 11期

关键词：

D O I：

10.1021/np020029b

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Twenty-six semisynthetic ent-kaurane derivatives of linearol (1) have been investigated for their anti-HIV effects. Five compounds (4, 7, 11, 25, and 26) showed significant activity against HIV replication in H9 lymphocyte cells with EC50 values in the range <0.1-3.11 μg/mL. With TI values of 163 and 184, compounds 4 and 25 are especially promising for further development as potential anti-HIV agents.

引用

页码：1594 / 1597

页数：4

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