Albidopyrone, a new α-pyrone-containing metabolite from marine-derived Streptomyces sp NTK 227

被引：27

作者：

Hohmann, Claudia ^{[1
]}

Schneider, Kathrin ^{[2
]}

Bruntner, Christina ^{[1
]}

Brown, Roselyn ^{[3
]}

Jones, Amanda L. ^{[3
]}

Goodfellow, Michael ^{[3
]}

Kraemer, Marco ^{[4
]}

Imhoff, Johannes F. ^{[4
]}

Nicholson, Graeme ^{[5
]}

Fiedler, Hans-Peter ^{[1
]}

Suessmuth, Roderich D. ^{[2
]}

机构：

[1] Univ Tubingen, Inst Mikrobiol, D-72076 Tubingen, Germany

[2] Tech Univ Berlin, Inst Chem, Berlin, Germany

[3] Univ Newcastle, Sch Biol, Newcastle Upon Tyne, Tyne & Wear, England

[4] IFM, GEOMAR, Inst Meereswissensch, Kiel, Germany

[5] Univ Tubingen, Inst Organ Chem, D-7400 Tubingen, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2009年 / 62卷 / 02期

关键词：

fermentation; isolation; marine Streptomyces; alpha-pyrone; protein-phosphatase inhibitor; structure elucidation; SECONDARY METABOLITES; PTP1B; NOV;

D O I：

10.1038/ja.2008.15

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Albidopyrone, a new alpha-pyrone-containing secondary metabolite, was produced by Streptomyces sp. NTK 227, a strain isolated from Atlantic Ocean sediment and found to be a member of the Streptomyces albidoflavus 16S rRNA gene clade. The structure of the compound was determined by MS and NMR spectroscopy, and found to have a moderate inhibitory activity against protein-tyrosin phosphatase B.

引用

页码：75 / 79

页数：5