A new approach to enantioselective cyanation of imines with Et2AlCN

被引：117

作者：

Nakamura, S ^{[1
]}

Sato, N ^{[1
]}

Sugimoto, M ^{[1
]}

Toru, T ^{[1
]}

机构：

[1] Nagoya Inst Technol, Grad Sch Engn, Dept Appl Chem, Showa Ku, Nagoya, Aichi 4668555, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 09期

关键词：

D O I：

10.1016/j.tetasy.2004.03.040

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An enantioselective Strecker-type reaction of imines with Et2AlCN in the presence of chiral additives has been examined. The enantioselectivity varied depending on the substituents of the imino group as well as the chiral additives used. Thus, alpha-aminonitriles were obtained in good yields with good en antioselectivities in the reaction of N-benzylidenebenzhydrylamine with Et2AlCN and BINOL. The reaction with excess BINOL gave the aminonitrile with reversed configuration. (C) 2004 Published by Elsevier Ltd.

引用

页码：1513 / 1516

页数：4

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