Multicenter linkage study of schizophrenia loci on chromosome 22q

被引：52

作者：

Mowry, BJ

Holmans, PA

Pulver, AE

Gejman, PV

Riley, B

Williams, NM

Laurent, C

Schwab, SG

Wildenauer, DB

Bauché, S

Owen, MJ

Wormley, B

Sanders, AR

Nestadt, G

Liang, KY

Duan, J

Ribble, R

Norton, N

Soubigou, S

Maier, W

Ewen-White, KR

deMarchi, N

Carpenter, B

Walsh, D

Williams, H

Jay, M

Albus, M

Nertney, DA

Papadimitriou, G

O'Neill, A

O'Donovan, MC

Deleuze, JF

Lerer, FB

Dikeos, D

Kendler, KS

Mallet, J

Silverman, JM

Crowe, RR

Levinson, DF

机构：

[1] Queensland Ctr Mental Hlth Res, Pk Ctr Mental Hlth, Wacol, Qld 4076, Australia

[2] Univ Queensland, Dept Psychiat, Brisbane, Qld, Australia

[3] MRC, Biostat Unit, Cambridge CB2 2BW, England

[4] Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA

[5] Northwestern Univ, ENH Res Inst, Evanston, IL USA

[6] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Dept Psychiat, Richmond, VA USA

[7] Cardiff Univ, Dept Psychol Med, Cardiff CF4 4XN, S Glam, Wales

[8] Hop La Pitie Salpetriere, Lab Genet Mol Neurotransmiss & Proc Neurogenerati, Paris, France

[9] Univ Bonn, Dept Psychiat, D-5300 Bonn, Germany

[10] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA

[11] Aventis Pharma SA, Evry, France

[12] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Australian Genome Res Facil, Parkville, Vic 3050, Australia

[13] Univ Naples 2, Clin Psichiatr, Naples, Italy

[14] Hlth Res Board, Dublin, Ireland

[15] State Mental Hosp, Haar, Germany

[16] Univ Athens, Sch Med, Dept Psychiat, GR-11527 Athens, Greece

[17] Queens Univ Belfast, Dept Psychiat, Belfast, Antrim, North Ireland

[18] Hadassah Hebrew Univ, Dept Psychiat, Med Ctr, Jerusalem, Israel

[19] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA

[20] Univ Iowa, Coll Med, Mental Hlth Clin Res Ctr, Iowa City, IA USA

[21] Univ Iowa, Coll Med, Dept Psychiat, Iowa City, IA USA

[22] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA

来源：

MOLECULAR PSYCHIATRY | 2004年 / 9卷 / 08期

关键词：

linkage (genetics); chromosomes; human; pair; 22; schizophrenia; genetics; molecular; medical;

D O I：

10.1038/sj.mp.4001481

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hypothesis of the existence of one or more schizophrenia susceptibility loci on chromosome 22q is supported by reports of genetic linkage and association, meta-analyses of linkage, and the observation of elevated risk for psychosis in people with velocardiofacial syndrome, caused by 22q11 microdeletions. We tested this hypothesis by evaluating 10 microsatellite markers spanning 22q in a multicenter sample of 779 pedigrees. We also incorporated age at onset and sex into the analysis as covariates. No significant evidence for linkage to schizophrenia or for linkage associated with earlier age at onset, gender, or heterogeneity across sites was observed. We interpret these findings to mean that the population-wide effects of putative 22q schizophrenia susceptibility loci are too weak to detect with linkage analysis even in large samples.

引用

页码：784 / 795

页数：12

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