Infection by hepatitis C virus through contaminated intravenous immune globulin: Results of a prospective national inquiry in France

被引：22

作者：

Lefrere, JJ

Loiseau, P

MartinotPeignoux, M

Mariotti, M

Ravera, N

Thauvin, M

Marcellin, P

Janot, C

机构：

[1] HOP ST LOUIS, CTR TRANSFUS, PARIS, FRANCE

[2] HOP BEAUJON, SERV HEPATOL, CLICHY, FRANCE

[3] AGENCE MED, DIRECT LAB & CONTROLES, PARIS, FRANCE

来源：

TRANSFUSION | 1996年 / 36卷 / 05期

关键词：

D O I：

10.1046/j.1537-2995.1996.36596282581.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: A recent hepatitis C virus (HCV) outbreak has been suspected of being caused by an infusion of intravenous immune globulin. Study Design and Methods: Three laboratories were mandated by the French regulatory agency to prospectively screen on a national scale those persons having received suspected batches: 233 exposed patients were recalled and tested for HCV antibody and for HCV RNA. Results: Nineteen patients (8.1%) were found positive for HCV RNA; 7 of these 19 were positive for the HCV antibody, Conclusion: The link between HCV infection and intravenous immune globulin was reinforced by the overrepresentation of the 2b genotype (58%), which contrasts with the low prevalence of this genotype in France (1%).

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收藏

页码：394 / 397

页数：4

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