Infection by hepatitis C virus through contaminated intravenous immune globulin: Results of a prospective national inquiry in France

被引：22

作者：

Lefrere, JJ

Loiseau, P

MartinotPeignoux, M

Mariotti, M

Ravera, N

Thauvin, M

Marcellin, P

Janot, C

机构：

[1] HOP ST LOUIS, CTR TRANSFUS, PARIS, FRANCE

[2] HOP BEAUJON, SERV HEPATOL, CLICHY, FRANCE

[3] AGENCE MED, DIRECT LAB & CONTROLES, PARIS, FRANCE

来源：

TRANSFUSION | 1996年 / 36卷 / 05期

关键词：

D O I：

10.1046/j.1537-2995.1996.36596282581.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: A recent hepatitis C virus (HCV) outbreak has been suspected of being caused by an infusion of intravenous immune globulin. Study Design and Methods: Three laboratories were mandated by the French regulatory agency to prospectively screen on a national scale those persons having received suspected batches: 233 exposed patients were recalled and tested for HCV antibody and for HCV RNA. Results: Nineteen patients (8.1%) were found positive for HCV RNA; 7 of these 19 were positive for the HCV antibody, Conclusion: The link between HCV infection and intravenous immune globulin was reinforced by the overrepresentation of the 2b genotype (58%), which contrasts with the low prevalence of this genotype in France (1%).

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收藏

页码：394 / 397

页数：4

相关论文

共 35 条

[21] RELATIONSHIP BETWEEN HEPATITIS-C VIRUS GENOTYPES AND SOURCES OF INFECTION IN PATIENTS WITH CHRONIC HEPATITIS-C [J].

PAWLOTSKY, JM ;

TSAKIRIS, L ;

ROUDOTTHORAVAL, F ;

PELLET, C ;

STUYVER, L ;

DUVAL, J ;

DHUMEAUX, D .

JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (06) :1607-1610

[22] HEPATITIS-C VIREMIA IN RECIPIENTS OF IRISH INTRAVENOUS ANTI-D IMMUNOGLOBULIN [J].

POWER, JP ;

LAWLOR, E ;

DAVIDSON, F ;

YAP, PL ;

KENNYWALSH, E ;

WHELTON, MJ ;

WALSH, TJ .

LANCET, 1994, 344 (8930) :1166-1167

[23] MOLECULAR EPIDEMIOLOGY OF AN OUTBREAK OF INFECTION WITH HEPATITIS-C VIRUS IN RECIPIENTS OF ANTI-D IMMUNOGLOBULIN [J].

POWER, JP ;

LAWLOR, E ;

DAVIDSON, F ;

HOLMES, EC ;

YAP, PL ;

SIMMONDS, P .

LANCET, 1995, 345 (8959) :1211-1213

[24] INTRAVENOUS IMMUNOGLOBULINS AND HEPATITIS-C TRANSMISSION IN HEALTHY PREGNANT-WOMEN [J].

REZNIKOFFETIEVANT, MF ;

DELACHAUX, Y ;

MARPEAU, L ;

COUROUCE, A .

LANCET, 1992, 340 (8825) :986-986

[25] TRANSMISSION OF VIRAL-INFECTIONS THROUGH INTRAVENOUS IMMUNE GLOBULIN [J].

SCHIFF, RI .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (24) :1649-1650

[26] NEUTRALIZING ANTIBODIES AGAINST HEPATITIS-C VIRUS AND THE EMERGENCE OF NEUTRALIZATION ESCAPE MUTANT VIRUSES [J].

SHIMIZU, YK ;

HIJIKATA, M ;

IWAMOTO, A ;

ALTER, HJ ;

PURCELL, RH ;

YOSHIKURA, H .

JOURNAL OF VIROLOGY, 1994, 68 (03) :1494-1500

[27] TYPING OF HEPATITIS-C VIRUS ISOLATES AND CHARACTERIZATION OF NEW SUBTYPES USING A LINE PROBE ASSAY [J].

STUYVER, L ;

ROSSAU, R ;

WYSEUR, A ;

DUHAMEL, M ;

VANDERBORGHT, B ;

VANHEUVERSWYN, H ;

MAERTENS, G .

JOURNAL OF GENERAL VIROLOGY, 1993, 74 :1093-1102

[28] HEPATITIS-C VIRUS-INFECTION IN HYPOGAMMAGLOBULINEMIC PATIENTS RECEIVING LONG-TERM REPLACEMENT THERAPY WITH INTRAVENOUS IMMUNOGLOBULIN [J].

TALIANI, G ;

GUERRA, E ;

ROSSO, R ;

BADOLATO, MC ;

LUZI, G ;

SACCO, G ;

LECCE, R ;

DEBAC, C ;

AIUTI, F .

TRANSFUSION, 1995, 35 (02) :103-107

[29]

WEILAND O, 1986, LANCET, V1, P976

[30] DETECTION OF ANTI-HCV ANTIBODIES IN IMMUNOGLOBULIN PREPARATIONS BY RECOMBINANT IMMUNOBLOT ASSAY [J].

WIRZ, M ;

GENTILI, G .

BIOLOGICALS, 1994, 22 (01) :7-11

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