DAMGO and DPDPE facilitation of brain stimulation reward thresholds is blocked by the dopamine antagonist cis-flupenthixol

被引：20

作者：

Duvauchelle, CL

Fleming, SM

Kornetsky, C

机构：

[1] Boston University School of Medicine, Lab. of Behavioral Pharmacology, L-602, Boston, MA 02118

[2] Department of Psychology, Arizona State University, Box 87114, Tempe

[3] College of Pharmacy, Division of Pharmacology/Toxicology, University of Texas, Austin

来源：

NEUROPHARMACOLOGY | 1997年 / 36卷 / 08期

关键词：

opioids; self-stimulation; ICS;

D O I：

10.1016/S0028-3908(97)00075-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of dopamine neurotransmission in opioid reward was investigated using a rate-independent measure for determining brain stimulation reward (BSR) thresholds. Intra-accumbens infusions of the mu- and delta-specific peptides, D-Ala(2), N-Me-Phe(4), Gly-ol(5)-Enkephalin and D-Pen(2), D-Pen(5)-Enkephalin caused significant lowering of BSR thresholds. The dopamine D1/D2 antagonist, cis-flupenthixol, blocked these effects at a dose that did not significantly alter thresholds when given alone. These data suggest both mu- and delta-opioid potentiation of BSR is dopamine dependent. (C) 1997 Elsevier Science Ltd.

引用

页码：1109 / 1114

页数：6

共 29 条

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