A general Staudinger protocol for solution-phase parallel synthesis

被引：40

作者：

Lindsley, CW ^{[1
]}

Zhao, Z ^{[1
]}

Newton, RC ^{[1
]}

Leister, WH ^{[1
]}

Strauss, KA ^{[1
]}

机构：

[1] Merck Res Labs, Technol Enabled Synth Grp, Dept Med Chem, W Point, PA 19486 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 25期

关键词：

reduction; azides; combinatorial chemistry;

D O I：

10.1016/S0040-4039(02)00827-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Staudinger reaction has been adapted for parallel synthesis by the application of fluorous-tethered triphenyl phosphine. The fluorous-tethered triphenylphosphine is expediently removed in parallel by FluoroFlash(TM) SPE columns to afford functionalized amines in high yields and purities. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：4467 / 4470

页数：4

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