Effects of Gekko sulfated polysaccharide on the proliferation and differentiation of hepatic cancer cell line

被引：63

作者：

Wu, XiongZhi ^{[1
]}

Chen, Dan ^{[1
]}

Xie, Guang-Ru ^{[1
]}

机构：

[1] Tianjin Med Univ, Canc Ctr Integrated Trad & Western Med, Canc Hosp Tianjin, Tianjin 300060, Hexi District, Peoples R China

来源：

CELL BIOLOGY INTERNATIONAL | 2006年 / 30卷 / 08期

关键词：

Gekko; sulfated polysaccharide; hepatocarcinoma; differentiation; proliferation;

D O I：

10.1016/j.cellbi.2006.04.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gekko swinhonis Guenther has been used as an anti-cancer drug in traditional Chinese medicine. Gekko sulfated polysaccharide (Gepsin) was investigated for its activity in hepatocellular carcinoma. Hepatocarcinoma cell line (Bel-7402) and liver cell line (L-02) were exposed to Gepsin (100 mu g/ml and 10 mu g/ml). Gepsin did not suppress the proliferation and viability of normal liver L-02 cells, but strongly inhibited the proliferation of hepatocarcinoma Bel-7402 cells. Gepsin did not induce the apoptosis of Bel-7402 cells, but blocked cells in G(2)/M phase. Treated with Gepsin, Bel-7402 cells showed ultrastructural features of differentiation. AFP secretion decreased while ALB secretion increased markedly on Gepsin-treated cells. The data show that Gepsin suppressed the proliferation and induced differentiation of hepatocarcinoma, but the toxicity to normal liver cells was negligible. (c) 2006 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.

引用

页码：659 / 664

页数：6

共 25 条

[1] Fucoidan induces apoptosis of human HS-Sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways [J].