Dynamics and inheritance of the endoplasmic reticulum

被引:112
作者
Du, YR
Ferro-Novick, S
Novick, P
机构
[1] Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA
关键词
endoplasmic reticulum; microtubule; motility; inheritance; segregation; nuclear envelope; actin;
D O I
10.1242/jcs.01286
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The endoplasmic reticulum (ER) consists of a polygonal array of interconnected tubules and sheets that spreads throughout the eukaryotic cell and is contiguous with the nuclear envelope. This elaborate structure is created and maintained by a constant remodeling process that involves the formation of new tubules, their cytoskeletal transport and homotypic fusion. Since the ER is a large, single-copy organelle, it must be actively segregated into daughter cells during cell division. Recent analysis in budding yeast indicates that ER inheritance involves the polarized transport of cytoplasmic ER tubules into newly formed buds along actin cables by a type V myosin. The tubules then become anchored to a site at the bud tip and this requires the Sec3p subunit of the exocyst complex. The ER is then propagated along the cortex of the bud to yield a cortical ER structure similar to that of the mother cell. In animal cells, the ER moves predominantly along microtubules, whereas actin fibers serve a complementary role. It is not yet clear to what extent the other components controlling ER distribution in yeast might be conserved in animal cells.
引用
收藏
页码:2871 / 2878
页数:8
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