The COPII cage:: unifying principles of vesicle coat assembly

被引：161

作者：

Gurkan, Cemal

Stagg, Scott M.

LaPointe, Paul

Balch, William E.

机构：

[1] Scripps Res Inst, Dept Cell, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Mol Cell, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Inst Childhood & Neglected Dis, La Jolla, CA 92037 USA

[4] Scripps Res Inst, Natl Resource Automated Mol Microscopy, La Jolla, CA 92037 USA

[5] Cyprus Inst Neurol & Genet, Dept Electron Microscopy & Mol Pathol, Nicosia, Cyprus

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm2025

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Communication between compartments of the exocytic and endocytic pathways in eukaryotic cells involves transport carriers-vesicles and tubules-that mediate the vectorial movement of cargo. Recent studies of transport-carrier formation in the early secretory pathway have provided new insights into the mechanisms of cargo selection by coat protein complex-II (COPII) adaptor proteins, the construction of cage-protein scaffolds and fission. These studies are beginning to produce a unifying molecular and structural model of coat function in the formation and fission of vesicles and tubules in endomembrane traffic.

引用

页码：727 / 738

页数：12

共 92 条

[1] Rab1 recruitment of p115 into a cis-SNARE complex: Programming budding COPII vesicles for fusion [J].