Increased lipid peroxidation in cerebrospinal fluid and plasma from patients with Creutzfeldt-Jakob disease

被引:23
作者
Arlt, S
Kontush, A
Zerr, I
Buhmann, C
Jacobi, C
Schröter, A
Poser, S
Beisiegel, U
机构
[1] Univ Hamburg, Hosp Eppendorf, Inst Med Biochem & Mol Biol, D-20246 Hamburg, Germany
[2] Univ Hamburg, Hosp Eppendorf, Neurol Clin, D-20246 Hamburg, Germany
[3] Univ Gottingen, Neurol Klin, D-3400 Gottingen, Germany
关键词
antioxidants; cerebrospinal fluid; Creutzfeldt-Jakob disease; lipid peroxidation; plasma; prion disease;
D O I
10.1006/nbdi.2002.0496
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Oxidative pathomechanisms play an important role in neurodegenerative diseases like Alzheimer's disease (AD). It has been shown that lipid peroxidation in cerebrospinal fluid (CSF) and plasma is increased in AD. To assess the role of oxidative stress in Creutzfeldt-Jakob disease (CJD), we investigated the oxidizability of lipids, the lipid composition and the levels of the antioxidants ascorbate and alpha-tocopherol in CSF and plasma of 15 CJD patients and 12 neurologically healthy controls. CSF and plasma lipid peroxidation was increased in CJD patients and polyunsaturated fatty acids were reduced in CSF of these patients. Ascorbate levels were lower in CSF and plasma of CJD patients, while alpha-tocopherol was found to be decreased in CSF but not in plasma. These results support the hypothesis that oxidative mechanisms are involved in the pathogenesis of CJD and provide a rationale for the use of antioxidants in the therapy of this disease. (C) 2002 Elsevier Science (USA).
引用
收藏
页码:150 / 156
页数:7
相关论文
共 41 条
[1]   Time-course of oxidation of lipids in human cerebrospinal fluid in vitro [J].
Arlt, S ;
Finckh, B ;
Beisiegel, U ;
Kontush, A .
FREE RADICAL RESEARCH, 2000, 32 (02) :103-114
[2]   Cerebrospinal fluid lipoproteins are more vulnerable to oxidation in Alzheimer's disease and are neurotoxic when oxidized ex vivo [J].
Bassett, CN ;
Neely, MD ;
Sidell, KR ;
Markesbery, WR ;
Swift, LL ;
Montine, TJ .
LIPIDS, 1999, 34 (12) :1273-1280
[3]   Creutzfeldt-Jakob disease and oxidative stress [J].
Bleich, S ;
Kropp, S ;
Degner, D ;
Zerr, I ;
Pilz, J ;
Gleiter, CH ;
Otto, M ;
Rüther, E ;
Kretzschmar, HA ;
Wiltfang, J ;
Kornhuber, J ;
Poser, S .
ACTA NEUROLOGICA SCANDINAVICA, 2000, 101 (05) :332-334
[4]   CHARACTERIZATION OF SUBPOPULATIONS OF LIPOPROTEIN PARTICLES ISOLATED FROM HUMAN CEREBROSPINAL-FLUID [J].
BORGHINI, I ;
BARJA, F ;
POMETTA, D ;
JAMES, RW .
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1995, 1255 (02) :192-200
[5]  
Brown AN, 1997, MED PROBL PERFORM AR, V12, P15
[6]   Spongiform encephalopathies - B lymphocytes and neuroinvasion [J].
Brown, P .
NATURE, 1997, 390 (6661) :662-663
[7]   Normal prion protein has an activity like that of superoxide dismutase [J].
Brown, DR ;
Wong, BS ;
Hafiz, F ;
Clive, C ;
Haswell, SJ ;
Jones, IM .
BIOCHEMICAL JOURNAL, 1999, 344 :1-5
[8]   CONTINUOUS MONITORING OF INVITRO OXIDATION OF HUMAN LOW-DENSITY LIPOPROTEIN [J].
ESTERBAUER, H ;
STRIEGL, G ;
PUHL, H ;
ROTHENEDER, M .
FREE RADICAL RESEARCH COMMUNICATIONS, 1989, 6 (01) :67-75
[9]  
Finckh B, 1999, METHOD ENZYMOL, V299, P341
[10]  
FREI B, 1993, J LIPID RES, V34, P2135