Structures of new flavonoids, erycibenins D, E, and F, and NO production inhibitors from Erycibe expansa originating in Thailand

被引：46

作者：

Morikawa, Toshio

Xu, Fengming

Matsuda, Hisashi

Yoshikawa, Masayuki ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

[2] Kinki Univ, Pharmaceut Res & Technol Inst, Higashiosaka, Osaka 5778502, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 11期

关键词：

Erycibe expansa; erycibenin; flavanol; flavan; nitric oxide inhibitor; rotenoid;

D O I：

10.1248/cpb.54.1530

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new flavanol, erycibenin D, and two new flavans, erycibenins E and F, were isolated from the stems of Erycibe expansa originating in Thailand. The structures of new flavonoids were elucidated on the basis of chemical and physicochemical evidence. In addition, the inhibitory activities of the isolated constituents from E. expansa on lipopolysaccharide-activated nitric oxide production in mouse peritoneal macrophages were examined. Among the principal constituents, two isoflavones, clycosin (IC50=13 mu M) and erythrinin B (18 mu M), and two rotenoids, deguelin (26 mu M) and rotenone (27 mu M), were found to show potent inhibitory activity.

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页码：1530 / 1534

页数：5

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