Dicers at RISC: The mechanism of RNAi

被引：216

作者：

Tijsterman, M ^{[1
]}

Plasterk, RHA ^{[1
]}

机构：

[1] Netherlands Inst Dev Biol, Hubrecht Lab, Ctr Biomed Genet, NL-3584 CT Utrecht, Netherlands

来源：

CELL | 2004年 / 117卷 / 01期

关键词：

D O I：

10.1016/S0092-8674(04)00293-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pathway of RNA interference starts when Dicer cuts dsRNA into small interfering RNAs (siRNAs) that subsequently target homologous mRNAs for destruction. microRNA processing from stem loop precursors similarly requires Dicer activity. Two papers in this issue of Cell now demonstrate that Dicer is also essential for the execution phase of RNAi and explore the distinct requirements for Dicers in the siRNA and miRNA pathways.

引用

页码：1 / 3

页数：3

共 10 条

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Lee, YS ;

Nakahara, K ;

Pham, JW ;

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CELL, 2004, 117 (01) :69-81

[8] R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway [J].

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SCIENCE, 2003, 301 (5641) :1921-1925

[9] Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA [J].

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[10] A Dicer-2-dependent 80S complex cleaves targeted mRNAs during RNAi in Drosophila [J].

Pham, JW ;

Pellino, JL ;

Lee, YS ;

Carthew, RW ;

Sontheimer, EJ .

CELL, 2004, 117 (01) :83-94

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