Regulating the regulator: an RNA decoy acts as an OFF switch for the regulation of an sRNA

被引：18

作者：

Mandin, Pierre ^{[1
]}

Gottesman, Susan ^{[1
]}

机构：

[1] NCI, Mol Biol Lab, Bethesda, MD 20892 USA

来源：

GENES & DEVELOPMENT | 2009年 / 23卷 / 17期

关键词：

Antisense regulation; chitoporin; chitobiose; Hfq; small RNA; ESCHERICHIA-COLI; MESSENGER-RNA; MICRORNA ACTIVITY; TARGETS; HFQ; DEGRADATION; REPRESSION; MECHANISMS; BACTERIA; STRESS;

D O I：

10.1101/gad.1846609

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Many bacterial small regulatory RNAs (sRNAs) pair with mRNA targets, stimulating or inhibiting mRNA stability and/or translation. Regulation of these sRNAs is usually due to tight transcriptional regulation of synthesis. In this issue of Genes & Development and a related paper in Molecular Microbiology, Figueroa-Bossi and colleagues (pp. 2004-2015) and Overgaard and colleagues report a novel regulatory mechanism in which induction of a competing mRNA acts to titrate away the sRNA, allowing expression of an otherwise strongly inhibited target gene.

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收藏

页码：1981 / 1985

页数：5

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