Synthesis of a new type of chiral amino phosphine ligands for asymmetric catalysis

被引：79

作者：

Wang, Y ^{[1
]}

Li, X ^{[1
]}

Ding, KL ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 12期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0957-4166(02)00324-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This article describes the synthesis of a new type of chiral amino phosphine ligands from an amino naphthol starting material derived by asymmetric 1-aminoalkylation of 2-naphthol with (R)-1-phenylethylamine and benzaldehyde. The asymmetric induction properties of the ligands in the Pd(0)-catalyzed allylic substitution of 1,3-diphenylprop-2-en-1-yl acetate with dimethyl malonate has also been investigated, with near-quantitative yields and ee of up to 72.2% of the product being obtained under the optimized reaction conditions. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1291 / 1297

页数：7

共 36 条

[1]

[Anonymous], ANGEW CHEM INT ED EN

[2]

[Anonymous], COMPREHENSIVE ASYMME

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