Carvedilol inhibits reactive oxygen species generation by leukocytes and oxidative damage to amino acids

被引：126

作者：

Dandona, P

Karne, R

Ghanim, H

Hamouda, W

Aljada, A

Magsino, CH

机构：

[1] SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Endocrinol Diabet & Metab, Buffalo, NY 14209 USA

[2] Kaleida Hlth, Buffalo, NY 14209 USA

来源：

CIRCULATION | 2000年 / 101卷 / 02期

关键词：

carvedilol; oxygen; leukocytes; amino acids;

D O I：

10.1161/01.CIR.101.2.122

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background-The purpose of this study was to test whether carvedilol has an antioxidant effect in humans in vivo. Methods and Results-We administered 3.125 mg of carvedilol twice daily to normal subjects for I week. ROS generation by polymorphonuclear leukocytes and mononuclear cells fell from 314+/-183.43 and 303+/-116 mV to 185+/-157 and 189+/-63 mV (P<0.025), respectively. m-Tyrosine fell from 4.24+/-0.99 to 4.03+/-0.97 ng/mL (P=0.01), and o-tyrosine fell from 4.59+/-1.10 to 4.24+/-0.99 ng/mL (P=0.004) in the absence of a change in phenylalanine concentrations. Conclusions We conclude that carvedilol significantly inhibits ROS generation by leukocytes and oxidative conversion of phenylalanine to m- and o-tyrosine.

引用

页码：122 / 124

页数：3

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