P2X receptors as cell-surface ATP sensors in health and disease

被引：702

作者：

Khakh, Baljit S.

North, R. Alan

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

[4] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

来源：

NATURE | 2006年 / 442卷 / 7102期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nature04886

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

P2X receptors are membrane ion channels activated by the binding of extracellular adenosine triphosphate ( ATP). For years their functional significance was consigned to distant regions of the autonomic nervous system, but recent work indicates several further key roles, such as afferent signalling, chronic pain, and in autocrine loops of endothelial and epithelial cells. P2X receptors have a molecular architecture distinct from other ion channel protein families, and have several unique functional properties.

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页码：527 / 532

页数：6

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