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Direct demonstration of the effects of repetitive transcranial magnetic stimulation on the excitability of the human motor cortex

被引：112
作者：
Di Lazzaro, V
Oliviero, A
Berardelli, A
Mazzone, P
Insola, A
Pilato, F
Saturno, E
Dileone, M
Tonali, PA
Rothwell, JC
机构：
[1] Univ Cattolica Sacro Cuore, Neurol Inst, I-00168 Rome, Italy
[2] Univ Roma La Sapienza, Dipartimento Sci Neurol, Ist Neurol Neuromed, IRCCS, Rome, Italy
[3] Neurochirurg CTO, I-00145 Rome, Italy
[4] Neurofisiol CTO, I-00145 Rome, Italy
[5] IRCCS Casa Sollievo Sofferenza, San Giovanni Rotondo, Italy
[6] Inst Neurol, Sobell Dept Neurophysiol, London WC1N 3BG, England
[7] UCL Natl Hosp Neurol & Neurosurg, London WC1N 3BG, England
来源：
EXPERIMENTAL BRAIN RESEARCH | 2002年 / 144卷 / 04期
关键词：
transcranial magnetic stimulation; plasticity; motor cortex; rTMS;
D O I：
10.1007/s00221-002-1106-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 [神经生物学];
摘要：
The effects of repetitive transcranial magnetic stimulation (rTMS; 20 stimuli at 5 Hz at 120% resting motor threshold intensity using a biphasic stimulus pulse) on the excitability of human motor cortex were investigated in two patients who had an electrode implanted into the cervical epidural space. The corticospinal D wave increased in amplitude with successive stimuli, and reached a maximum after three or five pulses. At this stage, the amplitude of the I waves was unchanged, but after a further 10 stimuli an additional I wave was recruited. Both effects were still evident 2 min after the end of the rTMS. The effects are compatible with a short-term increase in cortical excitability during suprathreshold rTMS.
引用
收藏
页码：549 / 553
页数：5
相关论文
共 25 条
[1]
AMASSIAN VE, 1997, ELECTROENCEPHALOGR C, V103, P179
[2]
Facilitation of muscle evoked responses after repetitive cortical stimulation in man [J].
Berardelli, A ;
Inghilleri, M ;
Rothwell, JC ;
Romeo, S ;
Currà, A ;
Gilio, F ;
Modugno, N ;
Manfredi, M .
EXPERIMENTAL BRAIN RESEARCH, 1998, 122 (01) :79-84
[3]
Studies of neuroplasticity with transcranial magnetic stimulation [J].
Cohen, LG ;
Ziemann, U ;
Chen, R ;
Classen, J ;
Hallett, M ;
Gerloff, C ;
Butefisch, C .
JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 1998, 15 (04) :305-324
[4]
Functional relevance of cross-modal plasticity in blind humans [J].
Cohen, LG ;
Celnik, P ;
PascualLeone, A ;
Corwell, B ;
Faiz, L ;
Dambrosia, J ;
Honda, M ;
Sadato, N ;
Gerloff, C ;
Catala, MD ;
Hallett, M .
NATURE, 1997, 389 (6647) :180-183
[5]
THE CHARACTERISTICS AND PHARMACOLOGY OF OLFACTORY CORTICAL LTP INDUCED BY THETA-BURST HIGH-FREQUENCY STIMULATION AND 1S,3R-ACPD [J].
COLLINS, GGS .
NEUROPHARMACOLOGY, 1994, 33 (01) :87-95
[6]
Effects of voluntary contraction on descending volleys evoked by transcranial electrical stimulation over the motor cortex hand area in conscious humans [J].
Di Lazzaro, V ;
Oliviero, A ;
Profice, P ;
Insola, A ;
Mazzone, P ;
Tonali, P ;
Rothwell, JC .
EXPERIMENTAL BRAIN RESEARCH, 1999, 124 (04) :525-528
[7]
Di Lazzaro V, 1998, J PHYSIOL-LONDON, V508, P625
[8]
Comparison of descending volleys evoked by transcranial magnetic and electric stimulation in conscious humans [J].
Di Lazzaro, V ;
Oliviero, A ;
Profice, P ;
Saturno, E ;
Pilato, F ;
Insola, A ;
Mazzone, P ;
Tonali, P ;
Rothwell, JC .
ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1998, 109 (05) :397-401
[9]
Di Lazzaro V, 2001, EXP BRAIN RES, V141, P121
[10]
DAILY REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) IMPROVES MOOD IN DEPRESSION [J].
GEORGE, MS ;
WASSERMANN, EM ;
WILLIAMS, WA ;
CALLAHAN, A ;
KETTER, TA ;
BASSER, P ;
HALLETT, M ;
POST, RM .
NEUROREPORT, 1995, 6 (14) :1853-1856
123