Plasmonic Intravascular Photoacoustic Imaging for Detection of Macrophages in Atherosclerotic Plaques

被引：162

作者：

Wang, Bo ^{[1
]}

Yantsen, Evgeniya ^{[1
]}

Larson, Timothy ^{[1
]}

Karpiouk, Andrei B. ^{[1
]}

Sethuraman, Shriram ^{[1
]}

Su, Jimmy L. ^{[1
]}

Sokolov, Konstantin ^{[1
,2
,3
]}

Emelianov, Stanislav Y. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Biomed Engn, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Imaging Phys, Houston, TX 77030 USA

来源：

NANO LETTERS | 2009年 / 9卷 / 06期

基金：

美国国家卫生研究院;

关键词：

IN-VIVO; OPTICAL CONTRAST; LIGHT-SCATTERING; GOLD; OXIDE; NANOPARTICLES; INFLAMMATION; TOMOGRAPHY; PARTICLES;

D O I：

10.1021/nl801852e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To detect macrophages in atherosclerotic plaques, plasmonic gold nanoparticles are introduced as a contrast agent for intravascular photoacoustic imaging. The phantom and ex vivo tissue studies show that the individual spherical nanoparticles, resonant at 530 nm wavelength, produce a weak photoacoustic signal at 680 nm wavelength while photoacoustic signal from nanoparticles internalized by macrophages is very strong due to the plasmon resonance coupling effect. These results suggest that intravascular photoacoustic imaging can assess the macrophage-mediated aggregation of nanoparticles and therefore identify the presence and the location of nanoparticles; associated with macrophage-rich atherosclerotic plaques.

引用

页码：2212 / 2217

页数：6

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