Low Florbetapir PET Uptake and Normal Aβ1-42 Cerebrospinal Fluid in an APP Ala713Thr Mutation Carrier

被引：6

作者：

Lombardi, Gemma ^{[1
]}

Berti, Valentina ^{[2
]}

Tedde, Andrea ^{[1
]}

Bagnoli, Silvia ^{[1
]}

Piaceri, Irene ^{[1
]}

Polito, Cristina ^{[2
]}

Lucidi, Giulia ^{[1
,3
]}

Ferrari, Camilla ^{[3
]}

Ginestroni, Andrea ^{[4
]}

Moretti, Marco ^{[4
]}

Pupi, Alberto ^{[2
]}

Nacmias, Benedetta ^{[1
]}

Sorbi, Sandro ^{[1
,3
]}

机构：

[1] Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Viale Pieraccini 6, I-50139 Florence, Italy

[2] Univ Florence, Nucl Med Unit, Dept Biomed Expt & Clin Sci Mario Serio, Florence, Italy

[3] IRCCS Don Gnocchi, Florence, Italy

[4] AOU Careggi, Neuroradiol Unit, Florence, Italy

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2017年 / 57卷 / 03期

关键词：

APP Ala713Thr; familial Alzheimer's disease; florbetapir PET; frontotemporal dementia; ITALIAN POPULATION-SAMPLE; ALZHEIMERS-DISEASE; A713T MUTATION; FRONTOTEMPORAL DEMENTIA; DIAGNOSTIC-CRITERIA; AMYLOID-BETA; GENE; BIOMARKERS; ATROPHY; VARIANT;

D O I：

10.3233/JAD-161170

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

According to the literature, the APP Ala713Thr mutation is associated with Alzheimer's disease and cerebral amyloid angiopathy. We describe a case of dementia clinically compatible with frontotemporal dementia in an APP Ala713Thr mutation carrier in which both [F-18] Florbetapir PET uptake and A beta(1-42) cerebrospinal fluid levels were normal. Further evidences are required to establish if this association is only incidental.

引用

页码：697 / 703

页数：7

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