Determination of flunarizine in rat brain by liquid chromatography-electrospray mass spectrometry

被引:14
作者
Fuh, MR [1 ]
Hsieh, CJ [1 ]
机构
[1] Soochow Univ, Dept Chem, Taipei, Taiwan
来源
JOURNAL OF CHROMATOGRAPHY B | 1999年 / 736卷 / 1-2期
关键词
flunarizine;
D O I
10.1016/S0378-4347(99)00454-5
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A rapid liquid chromatography-electrospray mass spectrometry (LC-ES-MS) assay for the determination of flunarizine (FZ) in rat brain has been developed. A C-18 column and an isocratic elution were employed for the separation. Using post-column split, 64% of the eluent was introduced into the ES-MS system for detection. The [M + H](+) (m/z 406) and a fragmented ion (m/z 203) were detected using selected ion monitoring. The linear range of this assay was good, ranging from 0.05 to 5 mu M (r(2) = 0.99). The intra- and inter-day precisions showed relative standard deviations ranging from 1.4% to 2.0% and 1.3% to 2.9%, respectively. The application of this newly developed method was demonstrated by examining the pharmacokinetics of FZ in rat brain. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:167 / 173
页数:7
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