Molecular stick-slip motion revealed by opening DNA with piconewton forces

被引：193

作者：

Bockelmann, U

EssevazRoulet, B

Heslot, F

机构：

[1] Ecole Normale Supérieure, LPMC, URA 1437, Paris, 75005

来源：

PHYSICAL REVIEW LETTERS | 1997年 / 79卷 / 22期

关键词：

D O I：

10.1103/PhysRevLett.79.4489

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We have pulled apart the two strands of a DNA double helix. The forces measured during this process show a sequence specific variation on the piconewton scale. Opening two helical molecules with the same sequence from opposite sides gives two signatures which are not simply related by symmetry. In a theoretical model, this is explained as a molecular stick-slip motion which does not involve instabilities and is determined by the sequence.

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页码：4489 / 4492

页数：4

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