Chemiluminescence determination of tiopronin by flow injection analysis based on cerium(IV) oxidation sensitized by quinine

被引：44

作者：

Zhao, YN

Baeyens, WRG

Zhang, XR

Calokerinos, AC

Nakashima, K

VanDerWeken, G

机构：

[1] UNIV ATHENS,ANALYT CHEM LAB,DEPT CHEM,GR-15771 ATHENS,GREECE

[2] NAGASAKI UNIV,SCH PHARMACEUT SCI,NAGASAKI 852,JAPAN

来源：

ANALYST | 1997年 / 122卷 / 02期

关键词：

tiopronin; chemiluminescence; flow injection analysis; pharmaceutical analysis; thiols;

D O I：

10.1039/a605703i

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A flow injection analysis method is proposed for the determination of tiopronin based upon the oxidation by cerium(IV) in dilute sulfuric acid medium and sensitized by quinine, With the peak height as a quantitative parameter applying optimum working conditions, tiopronin is determined over the 1-400 mu M range (150 mu l per injection, n = 10, r = 0.9994) with a detection Limit of 0.34 mu M and an RSD (n = 10) less than 2% at 20 and 50 mu M. The proposed method, combining the advantages of speed and sensitivity, was applied to the routine determination of tiopronin in a pharmaceutical preparation.

引用

页码：103 / 106

页数：4