Eradication of virus-infected T-cells in a case of adult T-cell leukemia/lymphoma by nonmyeloablative peripheral blood stem cell transplantation with conditioning consisting of low-dose total body irradiation and pentostatin

被引：14

作者：

Abe, Y ^{[1
]}

Yashiki, S

Choi, I

Hara, K

Matsushima, T

Nishimura, J

Inaba, S

Nawata, H

Muta, K

机构：

[1] Kyushu Univ, Dept Med & Bioregulatory Sci, Grad Sch Med Sci, Fukuoka 8128582, Japan

[2] Kagoshima Univ, Fac Med, Dept Virol, Kagoshima 890, Japan

[3] Kyushu Univ, Div Clin Immunol, Med Inst Bioregulat, Beppu, Oita, Japan

[4] Kyushu Univ Hosp, Blood Transfus Serv, Fukuoka 812, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2002年 / 76卷 / 01期

关键词：

adult T-cell leukemia/lymphoma nonmyeloablative hematopoietic stem cell transplantation;

D O I：

10.1007/BF02982725

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe the case of a 55-year-old man with adult T-cell leukemia/lymphoma (ATL) in first remission who underwent nonmyeloablative allogeneic peripheral blood stein cell transplantation with conditioning consisting of 4 courses of pentostatin and low-dose total body irradiation. Complete chimerism in peripheral blood was achieved on day 42 without severe myelo-suppression. Concomitantly, the proviral DNA load for human T-cell leukemia virus I (HTLV-I) in peripheral blood mononuclear cells decreased below detectable limits and was still undetectable on day 270. This fact indicates that eradication of ATL cells is feasible by induction of an alloimmune response without high-dose chemoradiotherapy.

引用

页码：91 / 93

页数：3

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