An implantable MEMS drug delivery device for rapid delivery in ambulatory emergency care

被引：76

作者：

Elman, N. M. ^{[1
]}

Duc, H. L. Ho ^{[1
]}

Cima, M. J. ^{[1
]}

机构：

[1] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA

来源：

BIOMEDICAL MICRODEVICES | 2009年 / 11卷 / 03期

关键词：

MEMS; Drug delivery; Trauma care; Emergency; Micro-implant; Rapid delivery; Ambulatory emergency care; Cardiac device; Bolus; Subcutaneous; Cardiac; CARDIOVERTER-DEFIBRILLATOR; SYNCOPE; MICROCHIP; SURVIVAL;

D O I：

10.1007/s10544-008-9272-6

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

We introduce the first implantable drug delivery system based on MEMS (Micro-Electro-Mechanical-Systems) technology specifically designed as a platform for treatment in ambulatory emergency care. The device is named IRD(3) (implantable rapid drug delivery device) and allows rapid delivery of drugs. Vasopressin was used as a model drug for in vitro tests as it is a commonly used drug for cardiac resuscitation. Experimental results reveal that the IRD(3) provides an effective method for rapid delivery without significant drug degradation. Several medical uses and delivery modalities for IRD(3) are proposed.

引用

页码：625 / 631

页数：7

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